NEUREGULIN REPELLENT SIGNALING VIA ERBB4 RESTRICTS GABAERGIC INTERNEURONS TO MIGRATORY PATHS FROM GANGLIONIC EMINENCE TO CORTICAL DESTINATIONS

Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations

Abstract Background Cortical GABAergic interneurons (INs) are generated in the medial ganglionic eminence (MGE) and migrate tangentially into cortex.Because most, if not all, migrating MGE-derived INs express the neuregulin (NRG) receptor, ErbB4, we investigated influences of Nrg1 isoforms and Nrg3 on IN migration through ventral telencephalon (vTe

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